Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding.

@article{Boura2007BothTN,
  title={Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding.},
  author={Evzen Boura and Jan Silh{\'a}n and P. T. D. Herman and Jaroslav Ve{\vc}eř and Miroslav {\vS}ulc and Jan Teisinger and Veronika Ob{\vs}ilov{\'a} and Tom{\'a}{\vs} Ob{\vs}il},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 11},
  pages={8265-75}
}
FoxO4 belongs to the "O" subset of forkhead transcription factors, which participate in various cellular processes. The forkhead DNA binding domain (DBD) consists of three-helix bundle resting on a small antiparallel beta-sheet from which two extended loops protrude and create two wing-like structures. The wing W2 of FoxO factors contains a 14-3-3 protein-binding motif that is phosphorylated by protein kinase B in response to insulin or growth factors. In this report, we investigated the role… CONTINUE READING

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