Both systemic and local application of Granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy

@article{Frank2008BothSA,
  title={Both systemic and local application of Granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy},
  author={Tobias Frank and Johannes Schlachetzki and Bettina G{\"o}ricke and Katrin Meuer and Gundula Rohde and Gunnar P. H. Dietz and Mathias B{\"a}hr and Armin Schneider and Jochen H Weishaupt},
  journal={BMC Neuroscience},
  year={2008},
  volume={10},
  pages={49 - 49}
}
The hematopoietic Granulocyte-Colony Stimulating Factor (G-CSF) plays a crucial role in controlling the number of neutrophil progenitor cells. Its function is mediated via the G-CSF receptor, which was recently found to be expressed also in the central nervous system. In addition, G-CSF provided neuroprotection in models of neuronal cell death. Here we used the retinal ganglion cell (RGC) axotomy model to compare effects of local and systemic application of neuroprotective molecules. We found… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 52 references

Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne • 2006
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