Both single-dose and repeated administration of clomipramine reduces the behavioural response to intrathecal capsaicin in mice.

@article{Rosland1989BothSA,
  title={Both single-dose and repeated administration of clomipramine reduces the behavioural response to intrathecal capsaicin in mice.},
  author={Jan Henrik Rosland and Steinar Hunskaar and Kjell Hole},
  journal={Pharmacology \& toxicology},
  year={1989},
  volume={65 3},
  pages={
          189-91
        }
}
Capsaicin injected intrathecally releases substance P from primary sensory nerve endings, and induces a pain related behaviour in mice consisting of licking, biting and scratching directed to the distal part of the body. This behavioural response was reduced by approximately 35% after intraperitoneal administration of clomipramine, 10 mg/kg, 1 hr in advance, and by 38% after repeated administration (10 mg/kg/day for 9 days). Twenty-four hr after the last repeated clomipramine injection, the… 

References

SHOWING 1-10 OF 20 REFERENCES
Influence of naloxone on the antinociceptive effects of some antidepressant drugs.
TLDR
The results suggest that the antinociceptive activity of these six antidepressant drugs in acute experimental pain could involve opiate mechanisms.
Effects of desipramine and chlorimipramine on buprenorphine analgesia in mice.
  • A. M. Ageel
  • Biology, Psychology
    Japanese journal of pharmacology
  • 1986
TLDR
Biochemical data suggested a greater role for brain 5-hydroxytryptamine (5-HT) than Noradrenaline in tricyclic analgesia than noradrenalin in tricycleclic antidepressant analgesia.
...
1
2
...