• DOI:10.1111/J.1600-0773.1989.TB01154.X
• Corpus ID: 31815553

Both single-dose and repeated administration of clomipramine reduces the behavioural response to intrathecal capsaicin in mice.

@article{Rosland1989BothSA,
  title={Both single-dose and repeated administration of clomipramine reduces the behavioural response to intrathecal capsaicin in mice.},
  author={Jan Henrik Rosland and Steinar Hunskaar and Kjell Hole},
  journal={Pharmacology \& toxicology},
  year={1989},
  volume={65 3},
  pages={
          189-91
        }
}

• J. Rosland, S. Hunskaar, K. Hole
• Published 1 September 1989
• Biology, Psychology, Medicine
• Pharmacology & toxicology

Capsaicin injected intrathecally releases substance P from primary sensory nerve endings, and induces a pain related behaviour in mice consisting of licking, biting and scratching directed to the distal part of the body. This behavioural response was reduced by approximately 35% after intraperitoneal administration of clomipramine, 10 mg/kg, 1 hr in advance, and by 38% after repeated administration (10 mg/kg/day for 9 days). Twenty-four hr after the last repeated clomipramine injection, the response after capsaicin was still reduced by 36%, indicating a long-lasting effect of repeated treatment. The results indicate that clomipramine has analgesic properties against pain of central origin both after single-dose and repeated administration.