Both serotonin and a nitric-oxide donor cause chloride secretion in rat colonocytes by stimulating cGMP.

@article{Stoner2001BothSA,
  title={Both serotonin and a nitric-oxide donor cause chloride secretion in rat colonocytes by stimulating cGMP.},
  author={Michael Stoner and John M. Kellum},
  journal={Surgery},
  year={2001},
  volume={130 2},
  pages={236-41}
}
BACKGROUND Previous studies have demonstrated that an antagonist of nitric oxide synthase inhibits neurally mediated chloride secretion in response to serotonin (5-HT). The purpose of this study was to demonstrate that chloride secretion in rat colonocytes that were caused by stimulation of neural 5-HT receptors is mediated by way of a nitrergic pathway that involves the activation of guanylate cyclase. METHODS The nitric oxide (NO) donor, diethylenetriamine/NO (DNO), was added to an enriched… CONTINUE READING