Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats.

@article{Wise1976BothPR,
  title={Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats.},
  author={R A Wise and Robert A. Yokel and Harriet deWit},
  journal={Science},
  year={1976},
  volume={191 4233},
  pages={1273-5}
}
Rats learned to press a lever for intravenous injections of amphetamine or apomorphine. They also learned to avoid the taste of saccharin which was associated with experimenter-administered amphetamine or with self-administered apomorphine. Thus these, and presumably other, self-administered drugs serve as compound pharmacological stimuli, having both positively reinforcing and aversive properties. 

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