Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake.

@article{Jiang1997BothPA,
  title={Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake.},
  author={Hongying Jiang and D S Ulme and G Dickens and A Chabuk and M Lavarreda and Philip Lazarovici and Gordon Guroff},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 11},
  pages={6835-7}
}
Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells. K-252a inhibits the effect of NGF on p140(trk) cells but not on p75(NGFR) cells; brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) cells. The data suggest that both… CONTINUE READING