Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats.

@article{Blank2008BothOH,
  title={Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats.},
  author={Edward W. Blank and Po-Yin Wong and Rajkumar Lakshmanaswamy and Raphael C. Guzman and Satyabrata Nandi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 9},
  pages={
          3527-32
        }
}
August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammary cancers in ovary-intact ACI rats. To determine the role of progesterone in mammary carcinogenesis, six-week-old intact and ovariectomized ACI rats were continuously exposed to… CONTINUE READING

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