Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

@article{Levison1993BothOA,
  title={Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain},
  author={Steven W. Levison and James E. Goldman},
  journal={Neuron},
  year={1993},
  volume={10},
  pages={201-212}
}
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726 Citations
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726 Citations

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Lineage, migration, and fate determination of postnatal subventricular zone cells in the mammalian CNS
TLDR
The developmental fates and migrational patterns of the immature cells in the sub-ventricular zone of the mammalian forebrain are examined by labeling postnatal rat SVZ cells by stereotactic injection of replication-deficient murine retroviruses bearing reporter genes.
Glial Cell Lineages in the Rat Cerebral Cortex
TLDR
Analysis of a large number of clones marked with retrovirus at various stages of embryonic life contained, with very few exceptions, either all astrocytes or all oligodendrocyes, suggesting that the ventricular zone contains separate progenitor cells for the two glial cell types.
Pax6 Expression Is Sufficient to Induce a Neurogenic Fate in Glial Progenitors of the Neonatal Subventricular Zone
TLDR
In vivo retro- and lenti-virus injections into the neonatal SVZ and in vitro gene transfer demonstrate that pax6 over-expression is sufficient to down-regulate olig2 and to promote a neuronal lineage development and migration pattern in olig2-expressing cells.
Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS.
Early patterns of migration, morphogenesis, and intermediate filament expression of subventricular zone cells in the postnatal rat forebrain
TLDR
Observations suggest that the expression of nestin and vimentin occurs after progenitors emigrate from the SVZ and that filament expression and contact with blood vessels represent an early stage of astrocyte differentiation.
The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated.
TLDR
The results suggest that temporally and spatially regulated environmental signals control the destiny of glial progenitors during postnatal development and provide additional evidence for a common progenitor for astrocytes and oligodendROcytes.
Divergent lineages for oligodendrocytes and astrocytes originating in the neonatal forebrain subventricular zone
TLDR
D discrete groups of clonally related cells, generated by infecting progenitor cells of the neonatal subventricular zone with a retroviral lineage tracer, were analyzed ultrastructurally and found to give rise to both astrocytes and oligodends during the peak of gliogenesis.
Glial cell lineage in vivo in the mouse cerebellum
TLDR
The results suggest that astrocytes/Bergmann glia, white matter astroCytes and oligodendrocycles immediately arise from separate glial precursors: these three glial lineages may diverge in the course of cerebellar development.
Neuronal Progenitor Cells Derived from the Anterior Subventricular Zone of the Neonatal Rat Forebrain Continue to Proliferatein Vitroand Express a Neuronal Phenotype
TLDR
The neuronal progenitor cells of the SVZa constitute a unique cell population with characteristics distinct from the cells of other germinal zones.
Cycling cells in the adult rat neocortex preferentially generate oligodendroglia
TLDR
Clonal clusters containing mature glia also contained less mature cells, indicating that clonally related progenitors do not differentiate synchronously in vivo, and slowly cycling cells from the SVZ continue to cycle, resulting in an accumulation of oligodendroglia in the neocortex.
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References

SHOWING 1-10 OF 55 REFERENCES
A clonal analysis of glial lineages in neonatal forebrain development in vitro
Embryonic divergence of oligodendrocyte and astrocyte lineages in developing rat cerebrum
Oligodendrocyte and astrocyte lineages were traced in rat forebrain sections using single- and double-label immunoperoxidase and indirect immunofluorescent techniques. Antibodies were directed…
Division of astroblasts and oligodendroblasts in postnatal rodent brain: Evidence for separate astrocyte and oligodendrocyte lineages
TLDR
The results confirm previous electron microscopic autoradiographic studies showing that the vast majority of proliferating cells in postnatal rat optic nerve have the morphologic characteristics of differentiating ASs or OLs.
Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum
TLDR
The authors' observations suggest that oligodendrocytes in the forebrain and cerebellum arise from cells of the subventricular zone adjacent to the ventricles and migrate into and through nearby white and gray matter.
Lineage of radial glia in the chicken optic tectum.
TLDR
To reconcile the observations that many radialglia are present early, that radial glia are among the last offspring of a multipotential stem cell, and that most clones contain only a single radial glial cell, it is suggested that the stem cell is, or becomes, a radial glio cell.
Development of glial cells in the cerebral wall of ferrets: Direct tracing of their transformation from radial glia into astrocytes
  • T. Voigt
  • Biology
    The Journal of comparative neurology
  • 1989
TLDR
Coronal sections of the cerebral wall from developing ferrets (newborn to adult) were double‐stained with antibodies to vimentin and glial fibrillary acidic protein (GFAP) and around this time the astrocytes gradually lost their vimentsin staining, and in the adult no vimentIn‐positive elements were seen except at the ependymal surface.
The generation of neurons and oligodendrocytes from a common precursor cell
Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo.
TLDR
The developmental profile of the O-2A cells in the rat forebrain in vivo showed a largely similar progression to that in culture, with a time lag of at least 6 days between GD3 expression and the onset of myelination.
Evidence for migration of oligodendrocyte–type-2 astrocyte progenitor cells into the developing rat optic nerve
TLDR
The results indicate that long-distance migration along the neural axis is characteristic only of progenitors of the O–2A lineage and may serve to distribute these cells to regions of the CNS that will become myelinated.
Development of macroglial cells in rat cerebellum. I. Use of antibodies to follow earlyin vivo development and migration of oligodendrocytes
TLDR
Using antibodies against ganglioside GD3 and galactocerebroside to follow the origin and development of rat cerebellar oligodendrocytes both in vitro and in vivo revealed that cells initially GD3+/GC− appeared to make the transition via GD3/GC+ cells to GD3−/GC+.
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