Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons. Evidence for a common mechanism of action.

@article{Wakade1983BothNG,
  title={Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons. Evidence for a common mechanism of action.},
  author={Arun R. Wakade and David H. Edgar and Hans Thoenen},
  journal={Experimental cell research},
  year={1983},
  volume={144 2},
  pages={377-84}
}
Neurons were dissociated from the sympathetic ganglia of embryonic chicks, and cultured in the absence of non-neuronal cells. Both nerve growth factor (NGF) and high concentrations of extracellular K+ supported neuronal survival, and these effects were independent of the presence of serum in the culture medium. Only 60% of the neurons survived in response to 35 mM K+, and survival was not increased when both NGF and K+ were present together. It was, however, possible to maintain essentially all… CONTINUE READING

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