Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito.

@article{Arai2001BothMX,
  title={Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito.},
  author={Meiji Arai and Oliver Billker and Howard R. Morris and Maria Panico and Melaine Delcroix and Duane Dixon and Steven V Ley and Robert E Sinden},
  journal={Molecular and biochemical parasitology},
  year={2001},
  volume={116 1},
  pages={17-24}
}
Gametogenesis of Plasmodium in vitro can be induced by the combined stimulus of a 5 degrees C fall in temperature and the presence of xanthurenic acid (XA). In-vitro experiments showed that P. gallinaceum (EC(50)=80 nM) is much more sensitive to XA than P. berghei (9 microM), P. yoelii (8 microM), and P. falciparum (2 microM). However, in the mosquito vector, we do not know whether the temperature shift and XA are the only gametocyte-activating factors (GAF), nor do we know with certainty the… CONTINUE READING

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