Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals.

Abstract

Cellular activation is critical for the propagation of human immunodeficiency virus type 1 (HIV-1) infection. It has been suggested that truly naive CD4(+) T cells are resistant to productive HIV-1 infection because of their constitutive resting state. Memory and naive CD4(+) T-cell subsets from 11 HIV-1-infected individuals were isolated ex vivo by a… (More)

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@article{Ostrowski1999BothMA, title={Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals.}, author={Michele Ostrowski and T. W. Chun and Shawn Justement and Ivette Motola and Michele Spinelli and Joseph W. Adelsberger and Linda A. Ehler and Seth Mizell and Charles Hallahan and Alessandro Fauci}, journal={Journal of virology}, year={1999}, volume={73 8}, pages={6430-5} }