Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system.

@article{Schlueter2003BothLA,
  title={Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system.},
  author={Dirk Schlueter and Lai-Yu Kwok and Sonja Luetjen and Sabine Soltek and Sigrid Hoffmann and Heinrich K{\"o}rner and Martina Deckert},
  journal={Journal of immunology},
  year={2003},
  volume={170 12},
  pages={6172-82}
}
Immunity to Toxoplasma gondii critically depends on TNFR type I-mediated immune reactions, but the precise role of the individual ligands of TNFR1, TNF and lymphotoxin-alpha (LTalpha), is still unknown. Upon oral infection with T. gondii, TNF(-/-), LTalpha(-/-), and TNF/LTalpha(-/-) mice failed to control intracerebral T. gondii and succumbed to an acute necrotizing Toxoplasma encephalitis, whereas wild-type (WT) mice survived. Intracerebral inducible NO synthase expression and-early after… CONTINUE READING

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