Both low and high serum IGF-I levels associate with cancer mortality in older men.

@article{Svensson2012BothLA,
  title={Both low and high serum IGF-I levels associate with cancer mortality in older men.},
  author={Johan Svensson and Daniel Carlzon and Max Petzold and Magnus K. Karlsson and {\"O}sten Ljunggren and {\AA}sa Tivesten and Dan Mellstr{\"o}m and Claes Ohlsson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 12},
  pages={
          4623-30
        }
}
BACKGROUND Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality. METHODS Serum IGF-I levels were measured in 2901 elderly men (mean age 75.4, range 69-81 yr) included in… 
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Both low and high serum IGF-1 levels associate with increased risk of cardiovascular events in elderly men.
TLDR
Both low and high serum IGF-1 levels are risk markers for CVD events in elderly men, and the association between high serumIGF-1 and CVD Events is mainly driven by CHD events.
IGF-I and IGFBP2 in peripheral artery disease: results of a prospective study
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Examination of the relationship between levels of IGF-I and IGFBP-2 with all-cause and CVD mortality in a prospective study of patients with lower-extremity peripheral artery disease (PAD) found increased IFGBP-2 concentration was significantly and independently associated with long-term CVD Mortality in patients withLower-Extremity PAD.
Low serum insulin-like growth factor-I (IGF-I) level is associated with increased risk of vascular dementia
Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis
TLDR
Both high and low levels of IGF‐1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality.
Hormones and cardiovascular disease in older men.
  • B. Yeap, L. Flicker
  • Medicine, Biology
    Journal of the American Medical Directors Association
  • 2014
Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival
TLDR
Higher prediagnosis circulating IGF-II and IGFBP-3 levels are associated with better pancreatic cancer survival among men but not women, and a greater understanding of how IGF signaling is related to pancreatic cancers survival could have utility in improving pancreaticcancer prognosis.
IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405
TLDR
Among patients with mCRC, high plasma IGF BP-3 and low IGFBP-7 were associated with longer OS and PFS and Extreme levels of adiponectin were associatedWith shorter PFS, suggesting potential avenues for prognostic and therapeutic innovation.
Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins.
TLDR
There was a high heritability for IGF-I and IGFBP-3, but a low heritabilityFor insulin secretion and insulin sensitivity in a group of elderly twins, which did not seem to be strongly genetically determined.
Patients with Alzheimer's Disease Have Increased Levels of Insulin-like Growth Factor-I in Serum but not in Cerebrospinal Fluid.
TLDR
In AD patients without major brain vascular comorbidities, serum but not CSF levels of IGF-I were increased after correction for covariates, and this association was strengthened by exclusion of patients receiving medical treatment.
The antagonistic pleiotropy of insulin‐like growth factor 1
TLDR
Examining prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer found two generalized patterns, suggesting that IGF- 1 signaling could be harmful in older adults, who may actually benefit from the attenuation of biological growth pathways.
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