Both low- and high-affinity CCK receptor states mediate trophic effects on rat pancreatic acinar cells.

Abstract

Cholecystokinin (CCK) stimulates the growth of pancreatic acinar cells. However, the molecular mechanisms involved in this trophic action are unknown. CCK binds to both high- and low-affinity receptor states, and these two states appear to activate separate sets of intracellular messengers and have opposite effects on amylase release. JMV-180 is a CCK… (More)

Topics

  • Presentations referencing similar topics