Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing.

@article{Venketaraman2008BothLA,
  title={Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing.},
  author={Vishwanath Venketaraman and Albert Lin and Amy Le and Scott C. Kachlany and Nancy D. Connell and Jeffrey B. Kaplan},
  journal={Microbial pathogenesis},
  year={2008},
  volume={45 3},
  pages={173-80}
}
Two virulence factors produced by the periodontopathogen Aggregatibacter actinomycetemcomitans are leukotoxin, a secreted lipoprotein that kills human polymorphonuclear leukocytes and macrophages, and poly-N-acetylglucosamine (PGA), a surface polysaccharide that mediates intercellular adhesion, biofilm formation and detergent resistance. In this study we examined the roles of leukotoxin and PGA in protecting A. actinomycetemcomitans cells from killing by the human macrophage cell line THP-1… CONTINUE READING

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