Both isoforms of ketohexokinase are dispensable for normal growth and development.

@article{Diggle2010BothIO,
  title={Both isoforms of ketohexokinase are dispensable for normal growth and development.},
  author={Christine P Diggle and Mike Shires and Crystal McRae and Dianne J Crellin and Joshua Fisher and Ian M. Carr and Alexander F. Markham and Bruce E. Hayward and Aruna Asipu and David T. Bonthron},
  journal={Physiological genomics},
  year={2010},
  volume={42A 4},
  pages={235-43}
}
Dietary fructose intake has dramatically increased over recent decades and is implicated in the high rates of obesity, hypertension, and type 2 diabetes (metabolic syndrome) in Western societies. The molecular determinants of this epidemiologic correlation are incompletely defined, but high-flux fructose catabolism initiated by ketohexokinase (Khk, fructokinase) is believed to be important. The Khk gene encodes two enzyme isoforms with distinctive substrate preferences, the independent… CONTINUE READING
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