Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells.

@article{Martin1997BothIA,
  title={Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells.},
  author={Ashley W. Martin and Balz Frei},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 8},
  pages={1583-90}
}
Oxidative modification of LDL by vascular cells has been proposed as a mechanism by which LDL becomes atherogenic. Antioxidants that can prevent LDL oxidation may therefore act as antiatherogens. We used endothelial cells (ECs) from human aortas (HAECs), human saphenous veins (HSECs), and bovine aortas (BAECs) to investigate the role of intracellular and extracellular vitamin C (ascorbate) in EC-mediated LDL modification. Incubation of LDL (0.1 mg protein per milliliter) with confluent HAECs in… CONTINUE READING