Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.

@article{Suchodolski2010BothHA,
  title={Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.},
  author={Paulette F. Suchodolski and Yoshihiro Izumiya and Blanca Lupiani and Dharani K. Ajithdoss and Lucy F. Lee and H Kung and Sanjay M. Reddy},
  journal={Virology},
  year={2010},
  volume={399 2},
  pages={
          312-21
        }
}
  • Paulette F. Suchodolski, Yoshihiro Izumiya, +4 authors Sanjay M. Reddy
  • Published in Virology 2010
  • Biology, Medicine
  • Marek' disease virus serotype-1, also know as Gallid herpesvirus 2 (GaHV-2), elicits T-cell lymphomas in chickens. The GaHV-2 genome encodes an oncoprotein, Meq, with similarity to the Jun/Fos family of proteins. We have previously shown that Meq homodimers are not sufficient to induce lymphomas in chickens. In this study, we investigated the role of Meq heterodimers in the pathogenicity of GaHV-2 by generating a chimeric meq gene, which contains the leucine zipper region of Fos (meqFos). A… CONTINUE READING

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