Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya.

@article{Williams2005BothHA,
  title={Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya.},
  author={Thomas N Williams and Sammy Wambua and Sophie Uyoga and Alex Macharia and Jedidah K Mwacharo and Charles R Newton and Kathryn Maitland},
  journal={Blood},
  year={2005},
  volume={106 1},
  pages={368-71}
}
Although the alpha+ thalassemias almost certainly confer protection against death from malaria, this has not been formally documented. We have conducted a study involving 655 case patients with rigorously defined severe malaria and 648 controls, frequency matched on area of residence and ethnic group. The prevalence of both heterozygous and homozygous alpha+ thalassemia was reduced in both case patients with severe malaria (adjusted odds ratios [ORs], 0.73 and 0.57; 95% confidence intervals [95… CONTINUE READING
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The pathophysiology of falciparum malaria

  • IA Clark, WB Cowden, FD. Ba
  • Pharmacol Ther
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