Both fis-dependent and factor-independent upstream activation of the rrnB P1 promoter are face of the helix dependent.

@article{Newlands1992BothFA,
  title={Both fis-dependent and factor-independent upstream activation of the rrnB P1 promoter are face of the helix dependent.},
  author={J T Newlands and C A Josaitis and Wilma Ross and Richard L Gourse},
  journal={Nucleic acids research},
  year={1992},
  volume={20 4},
  pages={
          719-26
        }
}
Transcription from the Escherichia coli rrnB P1 promoter is increased by a cis-acting sequence which extends upstream of the -35 hexamer to about -150 with respect to the transcription initiation site, the Upstream Activation Region (UAR). Activation by the UAR involves two components: (1) a trans-acting protein, Fis, which binds to three sites in the UAR between -60 and -150, and (2) the UAR sequences themselves which affect RNA polymerase (RNAP) activity independent of other proteins. We… CONTINUE READING

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