Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae.

@article{Ren2003BothF1,
  title={Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae.},
  author={Bing Ren and Alexander Szalai and Orlanda Thomas and Susan K. Hollingshead and David E. Briles},
  journal={Infection and immunity},
  year={2003},
  volume={71 1},
  pages={75-85}
}
Pneumococcal surface protein A (PspA), a virulence factor of Streptococcus pneumoniae, is exceptionally diverse, being classified into two major families which are over 50% divergent by sequence analysis. A family 1 PspA from strain WU2 was previously shown to impede the clearance of pneumococci from mouse blood and to interfere with complement deposition… CONTINUE READING