Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

@inproceedings{Sloan2013BothEA,
  title={Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing},
  author={Katherine Elizabeth Sloan and Sandy Mattijssen and Simon Lebaron and David Tollervey and Ger J. M. Pruijn and Nicholas James Watkins},
  booktitle={The Journal of cell biology},
  year={2013}
}
Human ribosome production is up-regulated during tumorogenesis and is defective in many genetic diseases (ribosomopathies). We have undertaken a detailed analysis of human precursor ribosomal RNA (pre-rRNA) processing because surprisingly little is known about this important pathway. Processing in internal transcribed spacer 1 (ITS1) is a key step that separates the rRNA components of the large and small ribosomal subunits. We report that this was initiated by endonuclease cleavage, which… CONTINUE READING

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