Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine.

Abstract

Incubation of BHK-21 hamster fibroblasts in a serum- and amino acid-deficient medium caused a 3-fold increase in the degradation of endogenous protein, a doubling of the degradation of endocytosed epidermal growth factor, and an eightfold increase in the degradation of endocytosed alpha 2-macroglobulin. 3-Methyladenine (3MA) inhibited the deprivation… (More)

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@article{Hendil1990BothEA, title={Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine.}, author={Klavs B. Hendil and A M Lauridsen and Per O. Seglen}, journal={The Biochemical journal}, year={1990}, volume={272 3}, pages={577-81} }