Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor

@article{Shipton2020BothDA,
  title={Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor},
  author={Megan Shipton and A. Riley and A. M. Rossi and C. Brearley and C. Taylor and B. L. Potter},
  journal={Journal of Medicinal Chemistry},
  year={2020},
  volume={63},
  pages={5442 - 5457}
}
  • Megan Shipton, A. Riley, +3 authors B. L. Potter
  • Published 2020
  • Chemistry, Medicine
  • Journal of Medicinal Chemistry
  • Chiral sugar derivatives are potential cyclitol surrogates of the Ca2+-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Six novel polyphosphorylated analogues derived from both d- and l-glucose were synthesized. Binding to Ins(1,4,5)P3 receptors [Ins(1,4,5)P3R] and the ability to release Ca2+ from intracellular stores via type 1 Ins(1,4,5)P3Rs were investigated. β-d-Glucopyranosyl 1,3,4-tris-phosphate, with similar phosphate regiochemistry and… CONTINUE READING
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