Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor

@article{Shipton2020BothDA,
  title={Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor},
  author={Megan Shipton and A. Riley and A. M. Rossi and C. Brearley and C. Taylor and B. L. Potter},
  journal={Journal of Medicinal Chemistry},
  year={2020},
  volume={63},
  pages={5442 - 5457}
}
  • Megan Shipton, A. Riley, +3 authors B. L. Potter
  • Published 2020
  • Chemistry, Medicine
  • Journal of Medicinal Chemistry
    • Chiral sugar derivatives are potential cyclitol surrogates of the Ca2+-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Six novel polyphosphorylated analogues derived from both d- and l-glucose were synthesized. Binding to Ins(1,4,5)P3 receptors [Ins(1,4,5)P3R] and the ability to release Ca2+ from intracellular stores via type 1 Ins(1,4,5)P3Rs were investigated. β-d-Glucopyranosyl 1,3,4-tris-phosphate, with similar phosphate regiochemistry and… CONTINUE READING
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    • 17
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    References

    SHOWING 1-10 OF 64 REFERENCES
    3-position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition.
    • 36
    Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.
    • 26
    d-chiro-Inositol Ribophostin: A Highly Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities
    • 3
    • PDF
    myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor.
    • 8
    • PDF
    Roles for hydroxyl groups of D-myo-inositol 1,4,5-trisphosphate in the recognition by its receptor and metabolic enzymes.
    • 37
    • PDF
    Identification of partial agonists with low intrinsic activity at the inositol-1,4,5-trisphosphate receptor.
    • 25
    Synthesis of selective non-Ca(2+)-mobilizing inhibitors of D-myo-inositol 1,4,5-trisphosphate 5-phosphatase.
    • 48
    Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.
    • 7
    • PDF
    Synthesis and Ca(2+)-release activity of D- and L-myo-inositol 2,4,5-trisphosphate and D- and L-chiro-inositol 1,3,4-trisphosphate.
    • 21
    Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.
    • 43