Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B.

@article{Miajlovi2007BothCA,
  title={Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B.},
  author={Helen Miajlovi{\'c} and Anthony Loughman and Marian Brennan and Dermot Cox and T. J. Foster},
  journal={Infection and immunity},
  year={2007},
  volume={75 7},
  pages={3335-43}
}
Staphylococcus aureus can stimulate activation and aggregation of platelets, which are thought to be factors in the development of infective endocarditis. Previous studies have identified clumping factor A (ClfA) and fibronectin binding proteins A and B (FnBPA and FnBPB) as potent platelet aggregators. These proteins are able to stimulate rapid platelet aggregation by either a fibrinogen- or a fibronectin-dependent process which also requires antibodies specific to each protein. Slower… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Biofilms and host response - helpful or harmful.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica • 2017

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…