Both chromosome 13 abnormalities by metaphase cytogenetics and deletion of 13q by interphase FISH only are prognostically relevant in multiple myeloma.

@article{Kaufmann2003BothC1,
  title={Both chromosome 13 abnormalities by metaphase cytogenetics and deletion of 13q by interphase FISH only are prognostically relevant in multiple myeloma.},
  author={Hannes Kaufmann and Elisabeth Kr{\"o}mer and Thomas Noesslinger and Ansgar Weltermann and Jutta Ackermann and Regina Reisner and Marianne Bernhart and Johannes Drach},
  journal={European journal of haematology},
  year={2003},
  volume={71 3},
  pages={
          179-83
        }
}
OBJECTIVES Deletion of chromosome 13q [del(13q)] has emerged as a major adverse prognostic factor in multiple myeloma (MM). Del(13q) is detected two to three times more frequently by interphase fluorescence in situ hybridization (FISH) than by metaphase cytogenetics (CG). However, it has remained unclear whether or not del(13q) detected by FISH only provides the same prognostic information as its detection by CG. METHODS We investigated the outcome of 118 consecutive patients with newly… CONTINUE READING

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