Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.

Abstract

Canalicular multispecific organic anion transporter (cMOAT/MRP2) is known to play a major role in the transport of anionic xenobiotics including many types of glucuronide and glutathione conjugates across the bile canalicular membrane. In the present study, the biliary excretion of telmisartan (BIBR 277) and its glucuronide was examined in Sprague-Dawley… (More)

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Cite this paper

@article{Nishino2000BothCA, title={Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.}, author={Atsushi Nishino and Yoshihisa Kato and Tatsuo Igarashi and Yuichi Sugiyama}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2000}, volume={28 10}, pages={1146-8} }