Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus.

@article{Akhisaroglu2003BothAA,
  title={Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus.},
  author={Mustafa Akhisaroglu and Radmila M. Manev and Ezgi Akhisaroglu and Tolga Uz and Radmila Manev},
  journal={Neuroreport},
  year={2003},
  volume={14 11},
  pages={
          1471-3
        }
}
S100B is a cytokine with neurotrophic and neurite-extending activity that has been implicated in the mechanism of action of anti-depressants and in the pathobiology of aging associated disorders such as Alzheimer's disease. The antidepressant fluoxetine increases hippocampal S100B content in young adult rats. In humans, brain levels of S100B mRNA and protein increase with advancing age. We assayed hippocampal S100B protein content in young (2 month) and old (24 month) mice, and in old mice… CONTINUE READING
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