Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans.

Abstract

Administration of erythropoietin (EPO) has been linked to cerebrovascular events. EPO reduces vascular conductance, possibly because of the increase in hematocrit. Whether EPO in itself affects the vasculature remains unknown; here it was evaluated in healthy males by determining systemic and cerebrovascular variables following acute (30,000 IU/d for 3 d; n… (More)
DOI: 10.1096/fj.11-193508

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