Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein.

@article{Zhao2009BothTA,
  title={Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein.},
  author={Bin Zhao and Joungmok Kim and Xin Ye and Zhi-chun Lai and Kun Liang Guan},
  journal={Cancer research},
  year={2009},
  volume={69 3},
  pages={1089-98}
}
The Yes-associated protein (YAP) transcription coactivator is a candidate human oncogene and a key regulator of organ size. It is phosphorylated and inhibited by the Hippo tumor suppressor pathway. TEAD family transcription factors were recently shown to play a key role in mediating the biological functions of YAP. Here, we show that the WW domain of YAP has a critical role in inducing a subset of YAP target genes independent of or in cooperation with TEAD. Mutation of the WW domains diminishes… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

WW domain interactions regulate the Hippo tumor suppressor pathway

Cell Death and Disease • 2011
View 5 Excerpts
Highly Influenced

Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2016
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…