Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor.

@article{Agarwal2007BothPA,
  title={Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor.},
  author={Sheetal Agarwal and Dhananjay Pal and Ashim K Mitra},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={339 1-2},
  pages={139-47}
}
Polarized epithelial non-human (canine) cell lines stably transfected with human or murine complementary DNA (cDNA) encoding for various efflux transporters (P-gp/MDR1, MRP1, MRP2, and Bcrp1) were used to study transepithelial transport of Lopinavir (LVR) and compare results with the MDCKII-wild type cells. These transmembrane proteins cause multidrug resistance by decreasing the total intracellular accumulation of drugs. Lopinavir efflux was directional and was completely inhibited by MK-571… CONTINUE READING

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