Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.

@article{Avula2018BothNA,
  title={Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.},
  author={Leela Rani Avula and Tiane Chen and Olga N Kovbasnjuk and Mark Donowitz},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2018},
  volume={314 1},
  pages={
          G81-G90
        }
}
The intestinal epithelial brush border Na+/H+ exchanger NHE3 accounts for a large component of intestinal Na absorption. NHE3 is regulated during digestion by signaling complexes on its COOH terminus that include the four multi-PDZ domain-containing NHERF family proteins. All bind to NHE3 and take part in different aspects of NHE3 regulation. Because the roles of each NHERF appear to vary on the basis of the cell model or intestinal segment studied and because of our recent finding that a… CONTINUE READING
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