Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression

@inproceedings{Hu2015BothMA,
  title={Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression},
  author={Xuming Hu and Jianqiang Ye and Aijian Qin and Haitao Zou and Hong-xia Shao and Kun Qian},
  booktitle={PloS one},
  year={2015}
}
MicroRNA-155 (miR-155) has been as an important controller of TLR3 signalling. However, the interactions between miR-155 and TLR3 are poorly understood. Here, we focused on the regulation of the relationship between miR-155 and TLR3. Sequence analyses and firefly luciferase reporter assay revealed that miR-155 target were present in the coding sequences (CDS) of TLR3. And the expression of the TLR3 protein could be inhibited by a miR-155 mimic or by a virally encoded orthologue in chick embryo… CONTINUE READING