Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression

@article{Hu2015BothMA,
  title={Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression},
  author={Xuming Hu and Jianqiang Ye and Aijian Qin and Haitao Zou and Hongxia Shao and Kun Qian},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
  • Xuming Hu, Jianqiang Ye, +3 authors Kun Qian
  • Published 2015
  • Biology, Medicine
  • PLoS ONE
  • MicroRNA-155 (miR-155) has been as an important controller of TLR3 signalling. However, the interactions between miR-155 and TLR3 are poorly understood. Here, we focused on the regulation of the relationship between miR-155 and TLR3. Sequence analyses and firefly luciferase reporter assay revealed that miR-155 target were present in the coding sequences (CDS) of TLR3. And the expression of the TLR3 protein could be inhibited by a miR-155 mimic or by a virally encoded orthologue in chick embryo… CONTINUE READING

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