Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner.

@article{Nordgren2014BothLA,
  title={Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner.},
  author={Johan Nordgren and Sumit Sharma and Filem{\'o}n Bucardo and Waqas Nasir and G{\"o}kçe G{\"u}naydın and Dj{\'e}n{\'e}ba Ouermi and L{\'e}on W. Nitiema and Sylvia Becker-Dreps and Jacques Simpore and Lennart Hammarstr{\"o}m and G{\"o}ran Larson and Lennart Svensson},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2014},
  volume={59 11},
  pages={
          1567-73
        }
}
BACKGROUND The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo-blood group antigens (HBGAs) in an RV genotype-dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit… CONTINUE READING

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