Both Interaction Surfaces within Cohesin's Hinge Domain Are Essential for Its Stable Chromosomal Association

@inproceedings{Mishra2010BothIS,
  title={Both Interaction Surfaces within Cohesin's Hinge Domain Are Essential for Its Stable Chromosomal Association},
  author={Ajay Mishra and Bin Hu and Alexander Kurze and Fr{\'e}d{\'e}ric Beckou{\"e}t and Ana-Maria Farcas and Sarah E. Dixon and Yuki Katou and Syma Khalid and Katsuhiko Shirahige and Kim Nasmyth},
  booktitle={Current Biology},
  year={2010}
}
BACKGROUND The cohesin complex that mediates sister chromatid cohesion contains three core subunits: Smc1, Smc3, and Scc1. Heterotypic interactions between Smc1 and Smc3 dimerization domains create stable V-shaped Smc1/Smc3 heterodimers with a hinge at the center and nucleotide-binding domains (NBDs) at the ends of each arm. Interconnection of each NBD through their association with the N- and C-terminal domains of Scc1 creates a tripartite ring, within which sister DNAs are thought to be… CONTINUE READING
18 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Similar Papers

Loading similar papers…