Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells.

@article{Yamazaki2010BothFA,
  title={Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells.},
  author={Miwa Yamazaki and Keiichi Ozono and Tomoko N. Okada and Kanako Tachikawa and Hiroki Kondou and Yasuhisa Ohata and Toshimi Michigami},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={111 5},
  pages={1210-21}
}
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by bone and exerts its function in the target organs by binding the FGF receptor (FGFR) and Klotho. Since recent studies suggested that extracellular inorganic phosphate (Pi) itself triggers signal transduction and regulates gene expression in some cell types, we tested the notion that… CONTINUE READING