Both Erk and p38 kinases are necessary for cytokine gene transcription.

@article{Carter1999BothEA,
  title={Both Erk and p38 kinases are necessary for cytokine gene transcription.},
  author={A Brent Carter and Martha M. Monick and Gary W. Hunninghake},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={20 4},
  pages={
          751-8
        }
}
A critical feature of sepsis-induced acute lung injury is the release of cytokines from endotoxin (LPS)- stimulated alveolar macrophages (AM). LPS is also known to activate various members of the mitogen- activated protein kinase (MAPK) family in other types of cells. In this study, we evaluated whether multiple members of the MAPK family regulate cytokine gene expression in LPS-stimulated AM. We found that LPS activates both the extracellular signal-regulated kinase (Erk) and p38 kinases, and… CONTINUE READING

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