Both ERK and JNK are required for enhancement of MD-2 gene expression during differentiation of HL-60 cells.


BACKGROUND INFORMATION MD-2 is associated with the extracellular domain of TLR4 (Toll-like receptor 4) and augments TLR4-dependent LPS (lipopolysaccharide) responses in vitro. Our previous investigation found that PMA-induced HL-60 cell differentiation to macrophages is associated largely with TLR2 and CD14 and, to a much lesser extent, with TLR4. RESULTS… (More)
DOI: 10.1042/BC20070140