Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation

@article{Zhang2016BothCA,
  title={Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation},
  author={Xurui Zhang and C. Ye and F. Sun and W. Wei and B. Hu and Jufang Wang},
  journal={PLoS ONE},
  year={2016},
  volume={11}
}
Persistent DNA damage is considered as a main cause of cellular senescence induced by ionizing radiation. However, the molecular bases of the DNA damage and their contribution to cellular senescence are not completely clear. In this study, we found that both heavy ions and X-rays induced senescence in human uveal melanoma 92–1 cells. By measuring senescence associated-β-galactosidase and cell proliferation, we identified that heavy ions were more effective at inducing senescence than X-rays. We… Expand
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