Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer

@article{Howell2011BothBV,
  title={Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer},
  author={G. Stanley Howell and Sally E. Carty and Michaele J. Armstrong and Shane O Lebeau and Steven P. Hodak and Christopher J. Coyne and Michael Stang and Kelly L. McCoy and Marina N. Nikiforova and Yuri E Nikiforov and Linwah Yip},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={18},
  pages={3566-3571}
}
This study was designed to examine the aggressive features of BRAF-positive papillary thyroid cancer (PTC) and association with age. We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age <65 years) PTC patients. Younger and elderly PTC patients had similar incidences of BRAF-positive tumors (41% vs. 38%; p = 0.67). The… CONTINUE READING

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Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid

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