Both AP-1 and NF-kappaB seem to be involved in tumour growth in an experimental rat hepatoma.

@article{MooreCarrasco2009BothAA,
  title={Both AP-1 and NF-kappaB seem to be involved in tumour growth in an experimental rat hepatoma.},
  author={Rodrigo Moore-Carrasco and S{\'i}lvia Busquets and Maite Figueras and Moorthy S S Palanki and Francisco Javier L{\'o}pez-Soriano and Josep Maria Argil{\'e}s},
  journal={Anticancer research},
  year={2009},
  volume={29 4},
  pages={1315-7}
}
Daily treatment of rats bearing Yoshida AH-130 ascites hepatoma with the nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) double inhibitors SP100030 and SP100207 at a dose of 5 mg/kg and 10 mg/kg of body weight, respectively, resulted in a clear inhibition of tumour growth. The decrease was not related to an altered cell cycle distribution of the tumour cell population suggesting a merely necrotic effect. The results presented confirm that both transcription factors are… CONTINUE READING

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