Botanical and Phytochemical Therapy of Acne: A Systematic Review

  title={Botanical and Phytochemical Therapy of Acne: A Systematic Review},
  author={Whitney A. Fisk and Hadar A Lev-Tov and Raja K. Sivamani},
  journal={Phytotherapy Research},
  pages={1137 - 1152}
Acne is prevalent among adolescents and adults with significant psychological effects. Standard oral and topical therapies can have significant side effects including skin irritation, gastrointestinal upset, and the development of drug‐resistant bacteria. The use of botanicals and phytochemicals in dermatological products is increasingly popular, and many patients are turning to these alternative therapies for treatment of acne. This study aimed to systematically review clinical studies that… 

Medicina alternativa à base de plantas medicinais no tratamento da acne

The research result showed a diversity of medicinal plants with significant potential in the treatment of acne, among them Camellia sinensis, Orthosiphon stamineus and Rosmarinus officinalis, which can be an alternative treatment for acne in relation to conventional therapies.

Phytochemicals in the treatment of hyperpigmentation

A review of the latest clinical studies using plant-derived compounds and their effectiveness in the management of hyperpigmentation disorders finds that plant derived compounds have a multitude of cellular actions for various dermatological diseases.


The main objectives of the present study were to formulate and to evaluate an anti-acne cream based on alcoholic extracts of Thymus vulgaris, Rosa centifolia, Rosmarinus officinalis and Saponaria

Dermatology: how to manage acne vulgaris

Topical retinoids are the drugs of choice for the treatment and maintenance therapy of patients with mild-to-moderate acne vulgaris and may be used alone or in combination with benzoyl peroxide and topical or oral antibiotics.

New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders

This nonsystematic review focuses on herbal drugs that were tested in controlled clinical studies or in scientifically sound preclinical studies and are intended to treat atopic dermatitis, herpes simplex, rosacea and acne vulgaris.

Treatment Modalities for Acne

Due to the increasing resistance of Propionibacterium acnes towards the available antibiotics, there is a need for new treatment methods and the lack of necessary evidence on the efficacy of CAM therapies makes it necessary for researchers to investigate these treatment options further.

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications, Nevertheless, potentially serious adverse events, including herb–drug interactions, have been described and the need to be vigilant when using herbal remedies, particularly in specific conditions, such as during pregnancy and in the paediatric population.

Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics.

Traditional and Recent Evidence on Five Phytopharmaceuticals from Rosa damascena Herrm.

Traditional information about R. damascena phytopharmaceuticals was extracted from three medieval manuscripts including “Al-Shamil fi al-Tibb” (13th century AD), “Qarabadin Salehi“ (1766), and “Zamir Kabir’ (1780) to show a wide gap between recent findings and traditional knowledge.

Fabrication and Characterization of Multiple Herbal Extracts-loaded Nanofibrous Patches for Topical Treatment of Acne Vulgaris

The present study has provided a facile approach to develop biocompatible polymers based electrospun fibrous patch for the efficient delivery of herbal extracts for topical skin therapy, opening new perspectives for a new generation of cosmetotextiles.



The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris.

Topical 2% green tea lotion is an effective, cost-effective treatment for mild-to-moderate acne vulgaris and its efficacy on acne severity is determined.


Evaluating the efficacy of a topica! plant complex treatment in acne vulga­ ris in 30 volunteers highlighted that the topica!, plant complex product improves the clinica! appearance of acne.

Management of acne vulgaris: an evidence‐based update

This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and

Effect of a Polyherbal Unani formulation in acne vulgaris: A preliminary study

It was concluded that PHUF can be used safely and effectively for the treatment of acne vulgaris and was found safe and fairly well accepted by the patients.

A systematic review of benzoyl peroxide for acne vulgaris

Although the results provide some evidence that BPO reduces acne-lesion count, the available evidence is not robust enough for firm conclusions and further research is needed.

Clinical considerations on the use of concomitant therapy in the treatment of acne

  • A. Alexis
  • Medicine, Biology
    The Journal of dermatological treatment
  • 2008
An update of recent advances and data regarding the concomitant use of various anti‐acne agents is provided.

Analysis of Chinese herbal creams prescribed for dermatological conditions

Greater regulation needs to be imposed on Chinese herbalists to prevent illegal and inappropriate prescribing of potent steroids.

Treatment of acne vulgaris with 2% topical tea lotion.

The 2% tea lotion has proved its efficacy as a topical therapy for acne vulgaris, which is a new natural plant extract, which lacks any side effects.