Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity

@article{Glaser1999BoswellicAA,
  title={Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity},
  author={Tamara Glaser and S. Winter and Peter Groscurth and Hasan Safayhi and E R Sailer and Hermann P. T. Ammon and Martin Schabet and Michael Weller},
  journal={British Journal of Cancer},
  year={1999},
  volume={80},
  pages={756 - 765}
}
SummarySteroids are essential for the control of oedema in human malignant glioma patients but may interfere with the efficacy of chemotherapy. Boswellic acids are phytotherapeutic anti-inflammatory agents that may be alternative drugs to corticosteroids in the treatment of cerebral oedema. Here, we report that boswellic acids are cytotoxic to malignant glioma cells at low micromolar concentrations. In-situ DNA end labelling and electron microscopy reveal that boswellic acids induce apoptosis… Expand
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Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism--the potential role of ceramide accumulation.
  • D. Omahen
  • Biology, Medicine
  • Medical hypotheses
  • 2011
TLDR
It is hypothesized that simultaneous blockade of the COX, lipoxygenase, and/or cytochrome p450-mediated pathways would lead to greater accumulation of intracellular AA, resulting in elevated ceramide levels, thereby priming glioma cells for treatment-induced apoptotic cell death. Expand
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