Corpus ID: 104078895

Boswellic Acid- Potential tumors suppressant terpenoid -Photochemistry, Extraction and Isolation Methods -A comprehensive review study

@article{Kumar2016BoswellicAP,
  title={Boswellic Acid- Potential tumors suppressant terpenoid -Photochemistry, Extraction and Isolation Methods -A comprehensive review study},
  author={Davinder Kumar and V. Kumar and Pawan Jalwal},
  journal={Journal of Pharmacognosy and Phytochemistry},
  year={2016},
  volume={5},
  pages={231-239}
}
Natural products had served as a major source of drugs for centuries and about half of the pharmaceuticals used today are derived from natural products. Medicinal plants are of important therapeutic aid for various ailments Herbal constituents continue to influence the medicines of today and up to 25% of all prescription drugs in the United States have at least one active ingredient that comes from plant extracts or synthesized plant compounds. Cancer is a group of diseases characterized by… Expand
1 Citations

Figures from this paper

Therapeutic Importance and Application of Boswellic Acid From the Plant Boswellia serrata
Traditionally, the gum resin produced from the Boswellia serrata plant has been used in as a therapeutical compound. The gum that contains a chemical known as boswellic acid, AKBA (3-O-acetyl-11Expand

References

SHOWING 1-10 OF 46 REFERENCES
Boswellic acids: biological actions and molecular targets.
TLDR
This review summarizes the biological actions of BAs on the cellular and molecular level and attempts to put the data into perspective of the beneficial effects manifested in animal studies and trials with human subjects related to inflammation and cancer. Expand
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, beta-boswellic acid and its structural related derivatives, has been usedExpand
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.
TLDR
The results of this study suggest the effectiveness of Boswellia serrata extract with defined content of boswellic acids in inducing dose-dependent antiproliferative effects on all human malignant cells tested. Expand
Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
TLDR
Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. Expand
Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model
TLDR
All fractions of frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines, and all exhibited anti-proliferative and pro-apoptotic activities against pancreatic tumors in the heterotopic xenograft mouse model. Expand
Molecular Determinants of the Response of Tumor Cells to Boswellic Acids
TLDR
This work has identified a panel of genes from diverse functional groups, which were significantly associated with sensitivity or resistance of α- or β-boswellic acids, such as transcription factors, signal transducers, growth regulating genes, genes involved in RNA and protein metabolism and others. Expand
Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway.
TLDR
Boswellic acids have anti-proliferation and anti-cancer effects on Hep G2 cells and may be a promising drug for the chemoprevention of liver cancer. Expand
Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity
TLDR
Boswellic acids are cytotoxic to malignant glioma cells at low micromolar concentrations and induce apoptosis, and synergize with the cytot toxic cytokine, CD95 ligand, in inducingglioma cell apoptosis. Expand
The Immunobiology of Mushrooms
TLDR
There is, at present, no scientific basis for the use of either mushrooms or mushroom extracts in the treatment of human patients but there is significant potential for rigorous research to understand the potential of mushrooms in human disease and thence to focus on appropriate clinical trials to demonstrate effectiveness and/ or potential toxicity. Expand
Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells.
TLDR
It is demonstrated that acetyl-keto-beta-boswellic acid (AKBA) inhibited cellular growth in several colon cancer cell lines and HCT-116 p53(-/-) cells were sensitized to the apoptotic effect of AKBA, suggesting that p21 may have protected cells against apoptosis by inducing a G1 arrest. Expand
...
1
2
3
4
5
...