Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.

@article{Sferra2012BoswelliaSA,
  title={Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.},
  author={Roberta Sferra and Antonella Vetuschi and Valentina Catitti and S Ammanniti and Simona Pompili and Dina Melideo and Giuseppe Frieri and Eugenio Gaudio and Giovanni Latella},
  journal={European review for medical and pharmacological sciences},
  year={2012},
  volume={16 11},
  pages={1484-98}
}
BACKGROUND Hepatic fibrosis is characterised by a progressive accumulation of fibrillar extracellular matrix (ECM) proteins, including collagen that occurs in chronic liver diseases. Transforming growth factor-beta1 (TGF-beta)/Smad3 signalling plays a major role in tissue fibrogenesis acting as a potent stimulus of ECM accumulation. AIM To evaluate the… CONTINUE READING