Boswellia serrata

@article{AbdelTawab2011BoswelliaS,
  title={Boswellia serrata},
  author={Mona Abdel-Tawab and Oliver Werz and Manfred Schubert-Zsilavecz},
  journal={Clinical Pharmacokinetics},
  year={2011},
  volume={50},
  pages={349-369}
}
Non-steroidal anti-inflammatory drug (NSAID) intake is associated with high prevalence of gastrointestinal or cardiovascular adverse effects. All efforts to develop NSAIDs that spare the gastrointestinal tract and the cardiovasculature are still far from achieving a breakthrough. In the last two decades, preparations of the gum resin of Boswellia serrata (a traditional ayurvedic medicine) and of other Boswellia species have experienced increasing popularity in Western countries. Animal studies… Expand
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Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
TLDR
Positive correlation of the antioxidant activity with the mechanism involved in the physiologic maintenance of the integrity and function of the intestinal epithelium is shown, supporting its use as safe adjuvant in patients affected by IBD. Expand
Therapeutic Importance and Application of Boswellic Acid From the Plant Boswellia serrata
  • R. Satpathy
  • Biology
  • Advanced Pharmacological Uses of Medicinal Plants and Natural Products
  • 2020
TLDR
The chemical nature and isolation of boswellic acid and its therapeutic importance have been highlighted and the compound shows beneficial effects in various pharmacological properties like immunomodulation activity, polyarthritis, activity against Hepatitis C-virus and other harmful microbes, Colitis and Crohn's disease, and so on. Expand
Boswellic acid – Medicinal use of an ancient herbal remedy
TLDR
It is hoped that this review will help researchers identify relevant research questions leading to the development of effective formulations and a better understanding of the safety of BA, with the aim of promoting it as a mainstream treatment for various diseases in clinical practice. Expand
Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
  • S. Umar, K. Umar, +6 authors H. Khan
  • Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2014
TLDR
The abilities to inhibit proinflammatory cytokines and modulation of antioxidant status suggest that the protective effect of Boswellia serrata extract on arthritis in rats might be mediated via the modulation of immune system. Expand
Analysis of Boswellic Acid Contents and Related Pharmacological Activities of Frankincense-Based Remedies That Modulate Inflammation
TLDR
High-quality frankincense extracts display powerful anti-inflammatory effectiveness against multiple targets which can be traced back to BAs as bioactive ingredients, which obviously correlate with the amounts of BAs they contain. Expand
Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease.
The link between diabetes and cognitive dysfunction has been reported in many recent articles. There is currently no disease-modifying treatment available for cognitive impairment. Boswellia serrata… Expand
Boswellic Acids as Promising Leads in Drug Development against Alzheimer’s Disease
TLDR
BAs can be considered as valuable scaffold/lead compounds for multi-targeted DMAs in anti-AD drug discovery and development based on the available in silico, in vitro, in vivo studies and clinical trials. Expand
Avicenna's Canon of Medicine: a review of analgesics and anti-inflammatory substances
TLDR
The aim of the present study was to provide a descriptive review of all anti-inflammatory and analgesic drugs presented in Avicenna`s Canon of Medicine, to help further research into the clinical benefits of new drugs for treatment of inflammatory diseases and pain. Expand
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
TLDR
The availability of all six major BAs could be confirmed in rat brain 8h after oral administration of 240mg/kg BSE to rats showing mean concentrations of 11.6ng/g for KBA, 37.5ng/ g for AKBA, 485.1ng/G for αBA, 1066.0ng /g for βBA, and 163.7ng / g for AβBA. Expand
Natural anti-inflammatory agents for the management of osteoarthritis
TLDR
This chapter deals with natural products, which can prove to be a boon in managing OA, and scientific evidence supporting the efficacy of these natural products is discussed. Expand
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References

SHOWING 1-10 OF 108 REFERENCES
Effects of Boswellia serrata gum resin in patients with ulcerative colitis.
TLDR
In patients suffering from ulcerative colitis grade II and III the effect of Boswellia serrata gum resin preparation (350 mg thrice daily for 6 weeks) on stool properties, histolopathology and scan microscopy of rectal biopsies, blood parameters including Hb, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils was studied. Expand
Boswellic acids in chronic inflammatory diseases.
  • H. Ammon
  • Chemistry, Medicine
  • Planta medica
  • 2006
TLDR
Clinical studies suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma using Oleogum resins from BOSWELLIA species. Expand
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
TLDR
The findings demonstrated an anti-inflammatory effect of sAKBA and indicated that P-selectin-mediated recruitment of inflammatory cells is a major site of action for this novel anti- inflammatory agent. Expand
Metabolism of Boswellic Acids in Vitro and in Vivo
TLDR
This study indicates that the efficacy of B. serrata extract may be enhanced by increasing the bioavailability of AKBA, the main active ingredients of boswellic acids, which is not deacetylated to KBA. Expand
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
TLDR
This study shows that a gum resin preparation from Boswellia serrata could be effective in the treatment of chronic colitis with minimal side effects. Expand
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.
TLDR
BA inhibited ulcer production non-specifically in all the experimental models, whereby, it is not possible to propose a single specific mechanism but it is possible that BA might be acting by increasing the gastric mucosal resistance and local synthesis of cytoprotective prostaglandins and inhibiting the leukotriene synthesis. Expand
Effects of Boswellia serrata in mouse models of chemically induced colitis.
TLDR
Boswellia does not ameliorate symptoms of colitis in chemically induced murine models and, in higher doses, may become hepatotoxic, suggesting that prolonged and uncontrolled intake of boswellia as an herbal supplement in inflammatory bowel disease and other inflammatory conditions should be considered. Expand
Acetyl-11-keto-β-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis
TLDR
Oral therapy with the Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, indicating that the anti-inflammatory actions of the Bos Wellia extract in IBD may be due in part to boswellic acids such as AKBA. Expand
Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity.
TLDR
This review provides the first comprehensive overview of all currently applied approaches taken to improve the risk-benefit ratio of NSAIDs focusing on the structure activity relationships and the respective mechanism of action underlying the individual approaches. Expand
Recent considerations in nonsteroidal anti-inflammatory drug gastropathy.
  • G. Singh
  • Medicine
  • The American journal of medicine
  • 1998
TLDR
Analysis of prospectively followed patient status and outcomes, drug side effects, and the economic impact of illness for >11,000 arthritis patients at 8 participating institutions in the United States and Canada indicates osteoarthritis and rheumatoid arthritis patients are 2.5-5.5 times more likely than the general population to be hospitalized for NSAID-related GI events. Expand
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