Bosutinib.

Abstract

Bosutinib (SKI-606) is a 7-alkoxy-3-quinolinecarbonitrile, which functions as a dual inhibitor of Src and Abl kinases. In biochemical and proliferation assays, the compound was shown to be active against src family kinases and Bcr-Abl at IC50s of 100 and 90 nM, respectively. The bcr-abl fusion gene product, a consecutively activated tyrosine kinase, which… (More)
DOI: 10.1007/978-3-642-01222-8_9

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Cite this paper

@article{Keller2010Bosutinib, title={Bosutinib.}, author={Gunhild Keller and Philippe Schafhausen and Tim Henrik Br{\"{u}mmendorf}, journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer}, year={2010}, volume={184}, pages={119-27} }