Bosentan reduces pulmonary artery pressure in high altitude residents.

@article{Kojonazarov2012BosentanRP,
  title={Bosentan reduces pulmonary artery pressure in high altitude residents.},
  author={Baktybek Kojonazarov and Jainagul Isakova and Bakytbek Imanov and Nurmira Sovkhozova and Talantbek Sooronbaev and Takeshi Ishizaki and Almaz A. Aldashev},
  journal={High altitude medicine & biology},
  year={2012},
  volume={13 3},
  pages={217-23}
}
UNLABELLED Endothelin-1 (ET-1) plays a critical role in the regulation of pulmonary vascular tone. The aim of this study was to investigate the role of ET-1 in the pathogenesis of high altitude pulmonary arterial hypertension (HAPH). METHODS Pulmonary artery pressure (PAP) was measured by echocardiography in permanent residents of the Kyrgyz Republic (3200-4000 m above sea level) both before and 3 h after a single oral dose of ET receptor antagonist, bosentan (125 mg). Plasma ET-1 levels were… CONTINUE READING
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