Bosentan preserves endothelial function in mice overexpressing APP

@article{Elesber2006BosentanPE,
  title={Bosentan preserves endothelial function in mice overexpressing APP},
  author={Ahmad A. Elesber and Piero Ovidio Bonetti and Julie E. Woodrum and Xiang-yang Zhu and Amir Lerman},
  journal={Neurobiology of Aging},
  year={2006},
  volume={27},
  pages={446-450}
}
This study was designed to test the hypothesis that Alzheimer's disease (AD) is associated with endothelial dysfunction and that chronic endothelin-1 antagonism preserves endothelial function in mice overexpressing the AD amyloid precursor protein (APP). Three groups of mice were studied: C57BL/6 (normal control, n = 6), transgenic mice overexpressing APP (Tg2576, n = 5), and Tg2576 mice fed Bosentan (100 mg/(kg day)(-1)), a combined endothelin A and B receptor antagonist, for 4 months (Tg2576… CONTINUE READING
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