Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial.

@article{Jas2008BosentanFT,
  title={Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial.},
  author={Xavier Ja{\"i}s and Andrea Maria D'armini and Pavel Jansa and Adam Torbicki and Marion Delcroix and Hossein Ardeschir Ghofrani and Marius M Hoeper and Irene M Lang and Eugene S. Mayer and Joanna W Pepke-Zaba and Lo{\"i}c Perchenet and Adele Morganti and G{\'e}rald Simonneau and Lewis J. Rubin},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={52 25},
  pages={2127-34}
}
OBJECTIVES Our goal was to investigate the effect of treatment with the oral dual endothelin receptor antagonist bosentan on the hemodynamics and exercise capacity of patients with chronic thromboembolic pulmonary hypertension (CTEPH). BACKGROUND CTEPH is characterized by vascular obstruction and remodeling, leading to increased pulmonary vascular resistance (PVR). Although pulmonary endarterectomy (PEA) is potentially curative, medical therapy is needed in patients with inoperable disease or… CONTINUE READING

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Chronic thromboembolic pulmonary hypertension: a review of current practice.

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